Your situation sounds very hard, I am so sorry that you have to deal with that. This is just my opinion but I don't think you're going to be able to help them very much. Maybe with a little cleaning now and then but as for things changing that's going to take a long time. All hoarders struggle with change.
It might be best for you to concentrate on your own family ~ husband, kids, house. That's an area you can have some control over. Keep your immediate family's environment as tidy and clean as possible. You'll feel good knowing you are handling things well in your own home.
If you want to set aside a few hours or a day every week to help your mom or sisters with some chores that are difficult for them you could do that. But realize that the really hard work of changing how they live is up to them.
To understand hoarding behavior check out some sites online. You'll have to learn also how to love them from a distance and let go of any guilt you feel.
all the best ~~